Worthe Holt, MD

Office of the CMO


Dr. Worthe S. Holt Jr. currently serves as Vice President; Office of the CMO, Humana, Inc. Dr. Holt is responsible for the operation of clinical collaborative activities, and integration of clinical and business decision making processes for this Fortune 100 organization. He also provides operational expertise, working nationally with clients and hospitals to support business development, clinical care, and trend management. He completed his undergraduate studies, medical degree, and residency in Family Medicine at Indiana University, and his Masters in Medical Management at Tulane University.  Dr. Holt also completed a Faculty Development Fellowship at the University of North Carolina at Chapel Hill.  Holt has 33 years of care delivery and administrative experience including VP/COO roles at both hospitals and health systems in Indiana, as well as residency directorships. Additionally, Holt has served as President of the Indiana Medical Licensing Board. He is a Past President of the Indiana Academy of Family Physicians and a member of the Board of Trustees of Franklin College.

Holt also serves as Major General, Special Assistant to the Commander, United States Africa Command.  In this role he provides policy representation on behalf of the Joint Chiefs of Staff.  This includes direct contribution to the development of U.S. National Security policies and their execution as well as negotiations with U.S. Ambassadors and host nation political and military leadership. The mission of United States Africa Command is to promote common interests throughout the world to strengthen security, support universal rights and population health, promote the rule of law, respond to crises, deter transnational threats, counter violent extremist organizations, counter illicit activities, support the State Partnership Programs, and promote respect for human rights. Previously, Holt has served as a Fighter Pilot / Physician (F-16, F-4) and Adjutant General – Air in the United States Air Force / Minnesota and Indiana Air National Guard.

His other interests include aviation, coaching high school ice hockey, marathon running, water/snow skiing, equestrian activities and music.  He lives with his wife, Marie Holt, DDS in Indianapolis, Indiana and has two adult sons as well as a daughter-in-law, all pursuing careers in law.


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